Zero. According to the MSDS, you would have to inhale 50,000 ppm for 6 hours a day for two years, and be a rat to develop endocrine tumors. Ergo, it's perfectly safe.
SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 05/26/2004
Date Updated: 03/07/2004
Version 1.3
Section 1 - Product and Company Information
Product Name 1,1,1,2-TETRAFLUOROETHANE, 99+%
Product Number 374334
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
1,1,1,2-TETRAFLUOROETHANE 811-97-2 No
Formula C2H2F4
Synonyms Arcton 134a * F 134a * FC 134a * Fron 134a * HCFC
134a * HFA 134a * HFC 134a * Khladon 134a *
Norflurane * R 134a * Refrigerant R134a *
1,1,1,2-Tetrafluoroethane *
1,2,2,2-Tetrafluoroethane * TG 134a
RTECS Number: KI8842500
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Caution: Avoid contact and inhalation. Caution: nonflammable
high-pressure gas. Target organ(s): Heart.
HMIS RATING
HEALTH: 1*
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
HEALTH: 1
FLAMMABILITY: 0
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
EXPLOSION HAZARDS
Container explosion may occur under fire conditions.
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Use water spray or fog nozzle to keep cylinder cool.
Move cylinder away from fire if there is no risk.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area and keep personnel upwind. Shut off leak if there
is no risk.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Ventilate area and wash spill site after material pickup is
complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe gas. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Cylinder temperature should not
exceed 125°F (52°C).
SPECIAL REQUIREMENTS
Contents under pressure.
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Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Mechanical exhaust required. Safety shower and eye bath.
WORK PRACTICES
Store and use with adequate ventilation.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator in nonventilated areas
and/or for exposure above the TLV or PEL.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Compressed gas
Property Value At Temperature or Pressure
Molecular Weight 102.03 AMU
pH N/A
BP/BP Range -26.5 °C 760 mmHg
MP/MP Range N/A
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Alkali metals.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
ALDRICH - 374334
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Hydrogen fluoride.
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Can cause severe frostbite.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract. Can
cause rapid suffocation.
Ingestion: May be harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Heart.
SIGNS AND SYMPTOMS OF EXPOSURE
May be harmful. Prolonged or repeated exposure to skin causes
defatting and dermatitis.
TOXICITY DATA
Inhalation
Rat
1,500,000 mg/m3
LC50
Inhalation
Mouse
1,700,000 mg/m3
LC50
CHRONIC EXPOSURE - CARCINOGEN
Species: Rat
Route of Application: Inhalation
Dose: 50000 PPM
Exposure Time: 6H/2Y
Frequency: I
Result: Tumorigenic:Neoplastic by RTECS criteria.
Endocrine:Tumors.
Section 12 - Ecological Information
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
APPROPRIATE METHOD OF DISPOSAL OF CONTAMINATED PACKAGING
Caution: no-return cylinder. Do not reuse. Empty cylinder will
contain hazardous residue. Follow proper disposal techniques.
Section 14 - Transport Information
DOT
Proper Shipping Name: 1,1,1,2-Tetrafluoroethane [or]
Refrigerant gas R 134a
UN#: 3159
Class: 2.2
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Packing Group: None
Hazard Label: Non-Flammable gas
PIH: Not PIH
IATA
Proper Shipping Name: 1,1,1,2-TETRAFLUOROETHANE
IATA UN Number: 3159
Hazard Class: 2.2
Section 15 - Regulatory Information
US CLASSIFICATION AND LABEL TEXT
US Statements: Caution: Avoid contact and inhalation. Caution:
nonflammable high-pressure gas. Target organ(s): Heart.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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